【专业课件】Hodgkin Disease内容预览：

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neoplastic disorder with development of specific infiltrate containing pathologic Reed-Sternberg cells. It usually arises in lymph nodes and spreads to contiguous groups. Extranodal presentation are rare. Disease is associated with defective cellular immunity.

Diagnosis of Hodgkin Disease
is based on microscopic examination of lymph node or other involved tissue
it requires identification of diagnostic Reed-Sternberg cells

Classical Hodgkin disease
lymphocyte rich
nodular sclerosis 1 and 2
mixed cellularity
lymphocyte depletion (LD)

pathologic documentation by hemopathologist
physical examination
documentation of B symptoms
laboratory evaluation
complete blood count, ESR
liver function tests
renal function tests
lactate dehydrogenase
chest radiograph
ultrasonography
CT scan of chest, abdomen and pelvis
bone marrow aspiration / biopsy (bilateral)

Essential under certain circumstances
liver biopsy
gallium scan
technetium bone scan
bone radiographs

MRI
bipedal lymphangiogram
staging laparotomy
Useful but not essential tests
cell-surface marker phenotypic analysis
gene rearrangement analysis

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